Conformation matters: siRNAs with antisense strands with 5'-(E)-vinyl-phosphonate-∝-L-LNA elicit stronger RNAi-mediated gene silencing than those with 5'-(E)-vinyl-phosphonate-LNA. Datta D, Kumar P, Mandal S , Krampert M , Egli M, Hrdlicka P, Manoharan M
Chem. Commun. (RSC) 2024, PMID: 39431399, Read Article

The Tautomeric State of N4-Hydroxycytidine within Base-Paired RNA. Besse I, Stiller C, Schroeder T, Schäd B, Grüne M, Dietsch J,  and Höbartner C
ACS Central Science 2024 Article in Press

Illuminating Neuropeptide Y Y4 Receptor Binding: Fluorescent Cyclic Peptides with Subnanomolar Binding Affinity as Novel Molecular Tools. Gleixner J, Kopanchuk S, Grätz L, Tahk M, Laasfeld T, Veikšina S, Höring C, Gattor A O, Humphrys L, Müller C, Archipowa N, Köckenberger J, Heinrich M, Kutta R, Rinken A, and Keller M
ACS Pharmacology & Translational Science. Article in Press.

Atomic Mutagenesis of N6-Methyladenosine Reveals Distinct Recognition Modes by Human m6A Reader and Eraser Proteins. Seitz F, Jungnickel T, Kleiber N, Kretschmer J, Dietzsch J, Adelmann J, Bohnsack K, Bohnsack M and Höbartner C Journal of the American Chemical Society, Read Abstract.