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Poster-Präsentationen
Ausgewählte Poster-Präsentationen
Oligonukleotid-Synthese
Investigating the Impact of Linear Flow Rate on Purification Performance (2024)
Reaction condition optimization to minimize hydrolysate formation in a maleimide-NHS esteroligonucleotide conjugation reaction (2024)
Synthesis, uptake and biological activity of multimers of C-miR146a: a conjugate of CpG-rich deoxynucleotide D19 and micro-RNA miR146a (2021)
An alternative desilylation condition using NH4F (2023)
Efficient cadmium removal via EDTA chelation (2023)
(see Video)
Scale-Up capsule filtration of oligonucleotide solutions for cGMP use (2022)
Optimization of IPRP-UPLC method to prevent PS to PO conversion on column (2022)
Oligonukleotid-Delivery
Evaluation of GalNAc assemblies to enable hepatic siRNA delivery and robust gene silencing (2023)
(see Video)
Safety, efficacy and biodistribution of LNP-formulated mRNA (2017)
Tools to monitor cell type-specific gene silencing and functional siRNA delivery (2013)
Oligonukleotid Lead Identifizierung
RNA-seq-based Nucleic Acid Therapeutics Lead Optimization (2024)
RNA-seq-based Nucleic Acid Therapeutics Lead Optimization (2023)
(Bio)analytik
Comparison of two Bioanalytical Assays – PNA-HPLC-Assay and LC-MS/MS-Assay (2024)
Auto MS/MS and targeted MS/MS in-depth qualitative and quantitative analysis of oligonucleotide synthesis products and side products (2023)
Optimized CID conditions for 24-75mer oligonucleotide MS/MS characterization (2023)
Bridging the MS/MS data gap in the field of nucleic acid and oligonucleotide-based
therapeutics (ebook; 2023)
Characterization of LNPs with SEC-MALS: Encapsulation Efficiency, Concentration, Size and Molecular Weight (2022)
Novel mass spectrometry-based sequencing method for modified sgRNA (2021)
Differentiation of Isobaric 3’-/5’-Oligonucleotide Clipping Products by Trapped Ion Mobility Spectrometry (2021)
Sequence verfication and side product identification of synthetic RNA oligonucleotides by LC-ESI_PASEF and Oligoquest software (2021)
Extended preclinical ocular biodistribution and pharmacodynamic profile of ISTH0 036, an antisense oligonucleotide targeting transforming growth factor beta 2 (TGF-β2) for the treatment of ophthalmic diseases (2018)
Preclinical profile of ISTH0036, a potent and selective antisense oligonucleotide targeting transforming growth factor beta 2 (TGF-β2) for the treatment of ophthalmic diseases (2015)
The analysis of a single stranded antisense oligonucleotide in plasma via lysation and hybridization with HPLC-fluorescence (2014)
Preclinical and clinical development of SYL040012 eye drops for the treatment of increased intraocular pressure associated to glaucoma (2013)