siRNA Down-regulation of the PATZ1 Gene in Human Glioma Cells Increases Their Sensitivity to Apoptotic Stimuli. Tritz R, Mueller BM, Hickey MJ, Lin AH, Gomez GG, Hadwiger P, Sah DW, Muldoon L, Neuwelt EA, Kruse CA. Cancer Ther. 2008;6(B):865-876. View Abstract on PubMed
Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection. Rodrigues CD, Hannus M, Prudêncio M, Martin C, Gonçalves LA, Portugal S, Epiphanio S, Akinc A, Hadwiger P, Jahn-Hofmann K, Röhl I, van Gemert GJ, Franetich JF, Luty AJ, Sauerwein R, Mazier D, Koteliansky V, Vornlocher HP, Echeverri CJ, Mota MM. Cell Host Microbe. 2008 Sep 11;4(3):271-82. View Abstract on PubMed
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Frank-Kamenetsky M, Grefhorst A, Anderson NN, Racie TS, Bramlage B, Akinc A, Butler D, Charisse K, Dorkin R, Fan Y, Gamba-Vitalo C, Hadwiger P, Jayaraman M, John M, Jayaprakash KN, Maier M, Nechev L, Rajeev KG, Read T, Röhl I, Soutschek J, Tan P, Wong J, Wang G, Zimmermann T, de Fougerolles A, Vornlocher HP, Langer R, Anderson DG, Manoharan M, Koteliansky V, Horton JD, Fitzgerald K. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11915-20. Epub 2008 Aug 11. View Abstract on PubMed
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Akinc A, Zumbuehl A, Goldberg M, Leshchiner ES, Busini V, Hossain N, Bacallado SA, Nguyen DN, Fuller J, Alvarez R, Borodovsky A, Borland T, Constien R, de Fougerolles A, Dorkin JR, Narayanannair Jayaprakash K, Jayaraman M, John M, Koteliansky V, Manoharan M, Nechev L, Qin J, Racie T, Raitcheva D, Rajeev KG, Sah DW, Soutschek J, Toudjarska I, Vornlocher HP, Zimmermann TS, Langer R, Anderson DG. Nat Biotechnol. 2008 May;26(5):561-9. Epub 2008 Apr 27. View Abstract on PubMed
A new helper phospholipid for gene delivery. Prata CA, Li Y, Luo D, McIntosh TJ, Barthelemy P, Grinstaff MW. Chem Commun (Camb). 2008 Apr 7;(13):1566-8. Epub 2008 Jan 29. View Abstract on PubMed
Lipophilic peptides for gene delivery. Prata CA, Zhang XX, Luo D, McIntosh TJ, Barthelemy P, Grinstaff MW. Bioconjug Chem. 2008 Feb;19(2):418-20. Epub 2008 Jan 11. View Abstract on PubMed
siRNA knock-down of mutant torsinA restores processing through secretory pathway in DYT1 dystonia cells. Hewett JW, Nery FC, Niland B, Ge P, Tan P, Hadwiger P, Tannous BA, Sah DW, Breakefield XO. Hum Mol Genet. 2008 May 15;17(10):1436-45. Epub 2008 Feb 7. View Abstract on PubMed
Heme oxygenase-1 is an anti-inflammatory host factor that promotes murine plasmodium liver infection. Epiphanio S, Mikolajczak SA, Gonçalves LA, Pamplona A, Portugal S, Albuquerque S, Goldberg M, Rebelo S, Anderson DG, Akinc A, Vornlocher HP, Kappe SH, Soares MP, Mota MM. Cell Host Microbe. 2008; 3,331-8. View Abstract on PubMed