Safety and Toxicity Analyses

  • Standard cytotoxicity and apoptosis assays
  • PBMC assays to measure oligonucleotide-induced cytokine response by  ELISA  
  • Off target analysis
    • by reporter plasmid analysis of on- and off-target sites
    • in cell lines endogenously expressing on- and off-target
    • by RNA-Seq
  • Clinical chemistry; analysis of different parameters like specific substrates, proteins or electrolytes from biological fluids like serum, plasma or urine