Safety and Toxicity Analyses
- Standard cytotoxicity and apoptosis assays
- PBMC assays to measure oligonucleotide-induced cytokine response by ELISA
- Off target analysis
- by reporter plasmid analysis of on- and off-target sites
- in cell lines endogenously expressing on- and off-target
- by RNA-Seq
- Clinical chemistry; analysis of different parameters like specific substrates, proteins or electrolytes from biological fluids like serum, plasma or urine
