Chemistry Manufacturing & Control (CMC) activities are an elementary part of the development process of a (bio-)pharmaceutical drug. Based on many years of expertise, Axolabs can offer extensive CMC activities and accompany its customers until the filing of an IND. 

Oligonucleotide and nucleic acid analysis (also as GMP service)

  • Characterization of single-stranded and double-stranded oligonucleotides by state-of-the-art mass spectrometry, uHPLC techniques
    • Method development
    • Method validation
  • Physicochemical characterization of oligonucleotides, e.g.,
    • Differential scanning calorimetry
    • Temperature-dependent UV/VIS and CD spectroscopy
    • Molar extinction coefficient determination
    • Dynamic light scattering (DLS)