CRO Services
Accelerate preclinical success with expert nucleic acid CRO services
Axolabs’ CRO platform provides comprehensive preclinical support for nucleic acid therapeutics, integrating advanced in silico design, preclinical screening, and in vitro testing to drive rapid lead optimization. Working in concert with our CDMO team, we ensure data-driven decisions and a smooth transition from discovery through to clinical development and commercial success.
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Axolabs’ CRO platform provides comprehensive preclinical support for nucleic acid therapeutics, integrating advanced in silico design, preclinical screening, and in vitro testing to drive rapid lead optimization. Working in concert with our CDMO team, we ensure data-driven decisions and a smooth transition from discovery through to clinical development and commercial success.
In silico & bioinformatics
Our proprietary algorithms predict off-target interactions and ensure species cross-reactivity before benchwork begins.
- In silico screening streamlines lead selection.
- Sequence-specific modelling reduces downstream failures.
Rational design & synthesis
We integrate chemical modifications to boost oligonucleotide stability, lower immunogenicity, and enable targeted delivery for various RNA therapeutics.
- Solid-phase synthesis at multiple scales.
- On-resin or post-synthetic conjugation for lipids, carbohydrates, peptides, antibodies and more.
Preclinical screening
Automated synthesis, rapid purification, and multiplexed assays let us quickly evaluate oligonucleotide libraries for efficacy, specificity, and safety.
- Parallel screening via Quantigene™, qPCR, RNA-Seq.
- Real-time data speeds up structure-activity relationship (SAR) studies.
Cell-based evaluations
Our robust in vitro platforms verify on-target effects, assess cytotoxicity, and measure immunostimulation, guiding early go/no-go decisions.
- xCELLigence® real-time monitoring of cell growth/viability.
- Flow cytometry for detailed phenotypic and surface-marker analysis.
Advanced bioanalytics
Specialized proprietary PNA-HPLC, LC-MS/MS, and cytokine profiling provide deep insight into oligonucleotide kinetics, biodistribution, metabolism, and immune responses.
- Extraction-free detection of single- and double-stranded oligonucleotides.
- MRM-based quantification of parent drug and metabolites using in-house synthesized reference standards.
mRNA analytics
Axolabs provides comprehensive analytical characterization and bioanalytical support for mRNA therapeutics and vaccines, covering critical quality attributes, biodistribution, and pharmacology.
- Over 150 validated analytical methods (e.g. identity, purity, capping efficiency, encapsulation).
- GLP/GCP-compliant bioanalysis (PK, biodistribution, protein expression) and pharmacology studies.
LNP Formulation Services
We offer cutting-edge lipid nanoparticle (LNP) formulation and characterisation services to support your LNP based RNA delivery needs. Our ready-to-use LNP batches are compatible with a wide range of nucleic acid cargos, including siRNA, ASO, miRNA, mRNA, and sgRNA, and are suitable for both in vitro and in vivo applications.
- Versatile Formulation: Customizable LNP systems designed to match your payload and therapeutic goals. Scalable for cell-based assays, rodent models, and higher-species studies.
- Extensive Lipid Library: Access proprietary and benchmark ionizable lipids to enable rational design and optimization of your LNP delivery platform.
- Integrated Development Support: From screening to scale-up, our experts collaborate with you to streamline formulation, process development, and manufacturing.
- Comprehensive Characterisation: Advanced analytics ensure quality, consistency, and performance
- Comprehensive Characterisation via advanced analytics ensure quality, consistency, and performance: Particle size, PDI, zeta potential, and encapsulation efficiency Lipid quantification and RNA integrity. Functional delivery confirmed via mRNA/protein expression and cell-type markers (e.g., Kupffer, stellate cells)
Contact us
Find out morePartner with a global leader in oligonucleotide research, development, and manufacturing. Whether you need early-stage optimization, large-scale GMP production, or specialized analytical support, Axolabs’ experts are ready to help. Get in touch to discuss your project, request a capabilities overview, or schedule a technical consultation.