Oligonucleotide and Nucleic Acid Analytics 

Characterization of single-stranded and double-stranded oligonucleotides by state-of-the-art mass spectrometry, HPLC and UPLC techniques

  • Method development
  • Established procedures for technology transfer to CMOs

Physicochemical and thermodynamic characterization of oligonucleotides (e.g. digital scanning calorimetry, temperature dependent UV-spectroscopy, extinction coefficient determination)

Oligonucleotide stability in biological matrices (liquid and solid)

Identification of oligonucleotide metabolites by LC/MS

mRNA identity

Characterization of nucleosides and nucleotides

Analysis of nucleic acid-protein interactions by Micro Scale Thermophoresis (MST)