Oligonucleotide Manufacturing 

Chemically modified oligonucleotides and conjugates using

  • Wide range of chemically modified building blocks
  • Fluorescent labels
  • Small molecule, peptide and carbohydrate conjugates (e.g. GalNAc cluster)
  • Various conjugation strategies and chemistries including modification of ligands

High quality oligonucleotides

  • High throughput synthesis for lead identification and lead optimization
  • Oligonucleotide synthesis up to multiple grams
  • Synthesis of drug substance for GLP-Tox studies
  • Synthesis of reference material and drug substance-related impurity markers

Oligonucleotide drug design

  • Bioinformatics for in silico sequence pre-selection
  • Rational oligonucleotide design tailored for specific delivery systems

Lipid synthesis

  • For LNP formulation of oligonucleotides
  • Set of proprietary lipids available

Long RNA/DNA

  • Single guide RNAs for CRISPR/Cas applications
  • Aptamers

Potency and stability improvement of oligonucleotide-based therapeutics by optimization of sequence, structure and chemistry

Regulatory documentation to support the preparation of the Chemistry, Manufacturing and Control (CMC) section for drug substance and drug product

Custom-tailored manufacturing process optimization to maximize yield and quality